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Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study

Journal of Nervous & Mental Disease - Published Ahead-of-Print - Last Updated: April 20, 2015

Camice Revier ; Ulrich Reininghaus ; Rina Dutta ; Paul Fearon ; Robin Murray ; Gillian Doody ; Tim Croudace ; Paola Dazzan ; Margaret Heslin ; Adanna Onyejiaka ; Eugenia Kravariti ; Julia Lappin ; Ben Lomas ; James B. Kirkbride ; Kim Donoghue ; Craig Morgan ; Peter B. Jones


It has long been held that schizophrenia and other psychotic disorders have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes from the AESOP-10 multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90% when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions were first described.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY)

Published in the Copyright (C) 2015 Wolters Kluwer Health, Inc.