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Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study
Journal of Nervous & Mental Disease - Published Ahead-of-Print - Last Updated: April 20, 2015
Camice Revier ; Ulrich Reininghaus ; Rina Dutta ; Paul Fearon ; Robin Murray ; Gillian Doody ; Tim Croudace ; Paola Dazzan ; Margaret Heslin ; Adanna Onyejiaka ; Eugenia Kravariti ; Julia Lappin ; Ben Lomas ; James B. Kirkbride ; Kim Donoghue ; Craig Morgan ; Peter B. Jones
It has long been held that schizophrenia and other psychotic disorders have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes from the AESOP-10 multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90% when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions were first described.
Published in the Copyright (C) 2015 Wolters Kluwer Health, Inc.