Welcome to the Schizophrenia Resource Centre

Welcome, this website is intended for healthcare professionals in EMEA with an interest in the treatment of schizophrenia. By clicking the link below you are declaring and confirming that you are a healthcare professional

You are here

What Is the Place of Clozapine in the Treatment of Early Psychosis in Canada?

Williams R, Malla A, Roy MA, Joober R, Manchanda R, Tibbo P, Banks N, Agid O.

Can J Psychiatry. 2016 May 18. pii: 0706743716651049. [Epub ahead of print]

Abstract
 

Research and development of early intervention (EI) services for first-episode psychosis have brought much-needed transformation of service delivery for this serious mental disorder to many jurisdictions. The effectiveness of the EI model of service delivery is contingent on timely access to all evidence-informed treatment interventions, including a rational approach to pharmacotherapy. In this perspective paper, we present a brief review of the well-established effectiveness of clozapine in patients who clearly show lack of response to regular antipsychotic therapy. We concentrate, in particular, on the need to identify eligibility for clozapine therapy very early on following failure of treatment on 2 antipsychotic medications. We suggest that attention to the low use of clozapine in the very early phase of treatment of psychosis may be of particular value, as the response to clozapine at this stage is likely to produce larger benefits in other domains of outcomes because of the greater retention of patients' personal and social agency.

© The Author(s) 2016.

Background to the Neuroscience-based nomenclature

PROF Ole Andreassen | V1 -HD 1080p

E-Alert

Subscribe to our E-Alert to keep up to date with the new items in the Resource Centre

search this site

Search form

New levels of schizophrenia care through optimal delivery of treatment

Available to download for your personal use - Professor Emsley presents a selection of slides from ‘Empowering the Healthcare community: Reaching new levels in schizophrenia care’ as developed by the PsyAcademy Continuous Treatment Expert Committee.

 

View the video

Therapeutic actions of antipsychotics

Download lectures and guides on antipsychotics by Dr. Stephen M. Stahl:

View the video

Share