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Interview with Shitij Kapur on Dopamine and the Aberrant Salience Hypothesis
Institute of Psychiatry, London, UK, 2013
Dr. Kapur explores two important concepts within his research into psychosis: that the onset of antipsychotic action is not delayed, it’s rapid; and his aberrant salience hypothesis.
- Has the aberrant salience hypothesis withstood scrutiny from colleagues?
- The mechanism involved in salience - you emphasise frontal striatal dopamine release and the effect on the reward system. Is it as simple as that or are there other factors?
- Do you think more symptoms could be explained by the dopaminergic model?
- The hypothesis emphasises the clear relationship between dopamine blockade and symptom improvement. What are the implications for clinical practice?
- Do you think that medical discontinuation can lead to a re-emergence of symptoms in most patients?
- Can the hypothesis explain the bizarreness of delusions?