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Oliver Howes Discusses his Research on Brain Imaging and the Dopamine System
Filmed at the Institute of Psychiatry, London, UK, 2013
Dr. Howes discusses his research on abnormalities in the dopamine system, focusing on increased dopamine synthesis and its relationship with prodromal symptoms and first episode psychosis
- Could you outline the work that your team has been doing detecting abnormalities in the dopamine system, using PET scanners?
- It’s not feasible to put all high-risk patients into a PET scanner, but are there more clinically feasible ways to identify those at high risk of developing schizophrenia?
- Your work has shown that the prodrome is a very active stage of the illness, neurobiologically and clinically. Would you agree?
- Your work could support the idea with intervening with dopamine blockade in at risk mental state patients. It’s a controversial area – what are your feelings?
- Lots of studies have reported on the use of psychosocial interventions in the prodrome could alter presynaptic dopamine synthesis. What do you think?
- Your research has updated our understanding of the dopamine hypothesis. Could you briefly give us the updated version?
- Where is your research going from here?