Welcome to the Schizophrenia Resource Centre

Welcome, this website is intended for healthcare professionals in EMEA with an interest in the treatment of schizophrenia. By clicking the link below you are declaring and confirming that you are a healthcare professional

You are here

Self-related networks and negative symptoms in psychotic disorders

Interview with Andre Aleman at EPA 2016

Andre Aleman-HD 1080p

Abstracts of the 24th European Congress of Psychiatry, European Psychiatry, Vol. 33, Supplement March 2016

S84 Self-related networks and negative symptoms in psychotic disorders

A. Aleman, Groningen, The Netherlands


Two factors of negative symptoms in schizophrenia have been consistently described based on factor analysis, “expressive deficits” and “social amotivation”. We aimed to investigate the putatively differential involvement of self-related networks, as measured with BOLD fMRI during a self-evaluation task, in two dimensions of negative symptoms in schizophrenia (reduced expression and social amotivation). 


Forty-five patients with a diagnosis of schizophrenia participated in an fMRI study in which they performed a self-evaluation task. The task comprised a self-reflection, close other-reflection, and a semantic (baseline) condition.We compared correlates of Expressive versus Social amotivation factors (summed items from the PANSS interview) for the contrasts self-baseline and self-other. Significance threshold was set at P< 0.05 family-wise error (FEW) corrected.


Social amotivation correlated significantly with selfevaluation vs. baseline in right and left ACC, and in the sulcus of frontal lateral lobe between inferior frontal triangularis and middle frontal gyrus. This was also significant, but less pronounced, in the direct comparison of social amotivation vs. expressive deficits scores (for the self-baseline contrast). No activation differences survived critical thresholds for the self-other contrast.


Differential neural correlates for the two dimensions of negative symptoms support the validity of this distinction based on factor analyses. Intact functioning of brain circuitry for selfreferential processing may be of relevance to actively seek social interaction. Disclosure of interest The author has not supplied his declaration of competing interest.


Stay informed

Subscribe to our E-Alert to keep up to date with the new items in the Resource Centre.

search this site

Search form

New levels of schizophrenia care through optimal delivery of treatment

Available to download for your personal use - Professor Emsley presents a selection of slides from ‘Empowering the Healthcare community: Reaching new levels in schizophrenia care’ as developed by the PsyAcademy Continuous Treatment Expert Committee.


View the video

Therapeutic actions of antipsychotics

Download lectures and guides on antipsychotics by Dr. Stephen M. Stahl:

View the video