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Self-related networks and negative symptoms in psychotic disorders
Interview with Andre Aleman at EPA 2016
Abstracts of the 24th European Congress of Psychiatry, European Psychiatry, Vol. 33, Supplement March 2016
S84 Self-related networks and negative symptoms in psychotic disorders
A. Aleman, Groningen, The Netherlands
Two factors of negative symptoms in schizophrenia have been consistently described based on factor analysis, “expressive deficits” and “social amotivation”. We aimed to investigate the putatively differential involvement of self-related networks, as measured with BOLD fMRI during a self-evaluation task, in two dimensions of negative symptoms in schizophrenia (reduced expression and social amotivation).
Forty-five patients with a diagnosis of schizophrenia participated in an fMRI study in which they performed a self-evaluation task. The task comprised a self-reflection, close other-reflection, and a semantic (baseline) condition.We compared correlates of Expressive versus Social amotivation factors (summed items from the PANSS interview) for the contrasts self-baseline and self-other. Significance threshold was set at P< 0.05 family-wise error (FEW) corrected.
Social amotivation correlated significantly with selfevaluation vs. baseline in right and left ACC, and in the sulcus of frontal lateral lobe between inferior frontal triangularis and middle frontal gyrus. This was also significant, but less pronounced, in the direct comparison of social amotivation vs. expressive deficits scores (for the self-baseline contrast). No activation differences survived critical thresholds for the self-other contrast.
Differential neural correlates for the two dimensions of negative symptoms support the validity of this distinction based on factor analyses. Intact functioning of brain circuitry for selfreferential processing may be of relevance to actively seek social interaction. Disclosure of interest The author has not supplied his declaration of competing interest.